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目的 探讨肝硬化患者血清TNF α、IL 8和 β2 MG的关系及意义。方法 用ELISA双抗体夹心法及放射免疫法检测了 30例肝硬化患者及 30例正常人血清中TNF α、IL 8和 β2 MG的浓度。结果 肝硬化患者血清中TNF α、IL 8和 β2 MG明显升高。TNF α、IL 8与血清GPT呈正相关 ,提示TNF α、IL 8在肝硬化时参与了肝细胞损害过程 ;β2-MG与血清GPT呈正相关 ,提示 β2 MG可间接反映肝病活动程度 ;TNF α与IL 8呈正相关 ,提示TNF α诱导了IL 8的产生。结论 炎症因子TNF α、IL 8参与了肝细胞损害过程 ,β2 MG可间接反映肝病活动程度。
Objective To investigate the relationship between serum TNF α, IL 8 and β 2 MG in cirrhotic patients and their clinical significance. Methods Serum levels of TNFα, IL 8 and β2 MG in 30 patients with cirrhosis and 30 normal controls were detected by ELISA double antibody sandwich method and radioimmunoassay. Results Serum levels of TNFα, IL 8 and β2 MG were significantly increased in patients with cirrhosis. TNFα, IL 8 and serum GPT were positively correlated, suggesting that TNFα, IL 8 involved in the process of liver cirrhosis hepatocellular damage; β2-MG and serum GPT was positively correlated, suggesting β2 MG may indirectly reflect the degree of liver disease activity; TNFα and IL 8 showed a positive correlation, suggesting that TNF α induced IL 8 production. Conclusion The inflammatory cytokines TNF α and IL 8 are involved in the process of liver cell damage. Β 2 MG indirectly reflects the degree of liver disease.