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将48例血压正常的T_2DM早期肾病合并SCH患者随机分为LT4治疗组和常规治疗组。结果 LT4组较常规组能更好的降低总胆固醇(TC)、TSH、Hcy、尿UAER、血CREA水平[(5.11±1.10对5.84±1.48)mmol/L,(2.28±0.61对7.38±1.52)m IU/L,(11.62±3.45对11.25±3.83)mmol/L,(59.27±42.54对79.02±53.92)μg/ml,(76.16±12.56对77.15±11.77)μmol/L,均P<0.05]。甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)LT4组治疗前后有所降低[(2.77±2.07对2.65±1.57)mmol/L,(2.82±0.97对2.73±0.72)m IU/L,但均P>0.05]。结论提示LT4治疗能改善T2DM早期肾病合并SCH患者的血脂谱,降低血浆同型半胱氨酸水平,减少尿白蛋白排泄率(UAER),降低血肌酐。
48 patients with normotensive T 2DM early nephropathy with SCH were randomly divided into LT4 treatment group and conventional treatment group. Results The levels of total cholesterol (TC), TSH, Hcy, urinary UAER and blood levels of CREA in LT4 group were significantly lower than those in the control group [(5.11 ± 1.10 vs 5.84 ± 1.48) mmol / L, (2.28 ± 0.61 vs 7.38 ± 1.52, (11.62 ± 3.45 versus 11.25 ± 3.83) mmol / L, (59.27 ± 42.54 vs 79.02 ± 53.92) μg / ml, (76.16 ± 12.56 vs 77.15 ± 11.77) μmol / L, all P <0.05]. (2.77 ± 2.07 vs 2.65 ± 1.57) mmol / L, (2.82 ± 0.97 vs 2.73 ± 0.72) mIU / L, before and after treatment with triglyceride (TG) and low density lipoprotein cholesterol (LDL- L, but all P> 0.05]. The results suggest that LT4 treatment can improve the blood lipid profile, reduce plasma homocysteine level, decrease urinary albumin excretion rate (UAER), and lower serum creatinine in patients with early stage renal disease and SCH.