【摘 要】
：
目的 探讨NF-КBp65蛋白和mRNA在鼻咽癌组织中的表达及其临床病理意义.方法 运用免疫组化和RT-PCR的方法检测NF-КBp65蛋白和mRNA在60例鼻咽癌和30例鼻咽炎组织中的表达,分析鼻咽癌组织NF-ΚBp65表达活性差异与鼻咽癌患者临床病理指标的相关性.结果 鼻咽癌组织中NF-КBp65蛋白和mRNA的表达明显高于鼻咽炎组织(P<0.05);鼻咽癌组织中NF-КBp65蛋白和mRNA的表达与肿瘤大小、淋巴结转移及临床分期有显著相关性(P<0.05);肿瘤体积越大、有淋巴结转移、临床分期越高的
【机 构】
：
广东省中山市中医院病理科 528400;新疆医科大学附属肿瘤医院病理科,乌鲁木齐;广东省中山市中医院科教科
论文部分内容阅读
目的 探讨NF-КBp65蛋白和mRNA在鼻咽癌组织中的表达及其临床病理意义.方法 运用免疫组化和RT-PCR的方法检测NF-КBp65蛋白和mRNA在60例鼻咽癌和30例鼻咽炎组织中的表达,分析鼻咽癌组织NF-ΚBp65表达活性差异与鼻咽癌患者临床病理指标的相关性.结果 鼻咽癌组织中NF-КBp65蛋白和mRNA的表达明显高于鼻咽炎组织(P<0.05);鼻咽癌组织中NF-КBp65蛋白和mRNA的表达与肿瘤大小、淋巴结转移及临床分期有显著相关性(P<0.05);肿瘤体积越大、有淋巴结转移、临床分期越高的鼻咽癌NF-КBp65蛋白和mRNA的表达越高.结论 NNF-КBp65表达高的鼻咽癌可能更具有侵袭性,预后更差.NF-КBp65在鼻咽癌发生发展过程中可能发挥着重要作用,是鼻咽癌患者独立的预后因子.
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