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目的:探讨晚发性维生素K缺乏与低钙血症致颅内出血的相关性。方法:回顾性分析41例病例,年龄1～3个月;其中男26例,女15例;单纯母乳喂养37例,混合喂养4例。41例均无外伤史及出血性疾病家族史。结果:41例均证实既有颅内出血又有血钙降低,且凝血酶原时间均延长。结论:维生素K缺乏合并血钙低时更易导致自发性出血,所以对于母乳喂养、低钙惊厥的小婴儿应常规给予维生素K预防量,并积极补钙治疗,以防止诱发颅内出血。
Objective: To investigate the relationship between late vitamin K deficiency and intracranial hemorrhage caused by hypocalcemia. Methods: A retrospective analysis of 41 cases, aged 1 to 3 months; 26 males and 15 females; breast-feeding in 37 cases, 4 were mixed feeding. None of the 41 patients had a history of trauma and a family history of hemorrhagic disease. Results: All the 41 cases confirmed that both intracranial hemorrhage and serum calcium decreased, and prothrombin time were prolonged. Conclusion: Vitamin K deficiency combined with low serum calcium more easily lead to spontaneous bleeding, so for breastfeeding, calcium deficiency convulsions in infants should be routinely given vitamin K prophylaxis and positive calcium treatment to prevent induced intracranial hemorrhage.