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目的 :探讨早期大剂量静脉丙种球蛋白治疗新生儿溶血病的效果。方法 :选择2015年11月至2016年11月期间我院收治的80例溶血病新生儿作为研究对象,并随机分为观察组和对照组,对照组采取常规治疗,观察组在常规治疗的基础上给予早期静脉滴注丙种球蛋白。结果 :观察组治疗后24h、72h的血清总胆红素水平均低于对照组,差异有统计学意义(P<0.05);观察组患儿的光疗时间、住院时间、黄疸消退时间等均低于对照组,差异有统计学意义(P<0.05)。结论 :对新生儿溶血病患儿给予早期静脉滴注丙种球蛋白可显著改善患儿的临床症状,缩短治疗时间,值得在临床上推广。
Objective: To investigate the effect of high dose intravenous gamma globulin in the treatment of neonatal hemolytic disease. Methods: From November 2015 to November 2016, 80 hemolytic disease newborns admitted to our hospital from January 2015 to November were selected as study subjects and randomly divided into observation group and control group. The control group received routine treatment. The observation group was treated on the basis of routine treatment On the given early intravenous gamma globulin. Results: The levels of serum total bilirubin in observation group at 24h and 72h after treatment were lower than those in control group (P <0.05). The phototherapy time, hospitalization time and jaundice remission time were all lower in observation group In the control group, the difference was statistically significant (P <0.05). Conclusion: The early intravenous infusion of gamma globulin in children with hemolytic disease can significantly improve the clinical symptoms and shorten the treatment time, which is worth popularizing clinically.