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糖尿病是一种以高血糖为特征的代谢性疾病.持续的高血糖会导致许多并发症的产生,如视网膜、肾脏、神经系统病变、血管并发症以及骨折等.随着中国逐步进入老龄化社会,糖尿病合并骨折患病人数快速增长.近些年来,通过国内外学者对糖尿病常用药的不断研究探索,糖尿病常用药物与骨折风险的联系逐步被人们认知.本文将围绕噻唑烷二酮类药物、钠-葡萄糖协同转运蛋白2抑制剂、磺脲类药物、二甲双胍类药物、胰岛素、肠促胰素以及二肽基肽酶-4抑制剂等糖尿病常用药与骨折风险关联性的研究进展进行综述.“,”Diabetes mellitus ( DM) is a metabolic disease characterized by hyperglycemia.Sustained hyperglycemia can lead to many complica-tions such as: retina, kidney, nervous system lesions, vascular compli-cations and fractures.As China gradually enters an aging society , the number of patients suffering from DM and fractures has increased signifi-cantly.In recent years, through continuous research and exploration of commonly used drugs for diabetes by scholars at home and abroad , the link between commonly used drugs for diabetes and fracture risk has been gradually recognized.This article focused on the latest development in the study of the association between fracture risk and commonly used drugs for diabetes such as thiazolidinediones , sodium -glucose co -transporter 2 inhibitors, sulfonylureas, metformin drugs, insulin, incre-tins, and dipeptidyl peptidase -4 inhibitors.