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目的:观察大剂量高聚金葡素注射液分别联合奥沙利铂、顺铂腹膜腔内灌注治疗恶性腹腔积液的临床疗效及不良反应。方法:60例癌性腹腔积液患者分为A组32例,B组28例。A组采用腹膜腔内置细导管持续引流后腹腔内灌注大剂量高聚金葡素注射液联合奥沙利铂;B组采用腹膜腔内置细导管持续引流后腹腔内灌注大剂量高聚金葡素注射液联合顺铂。每周治疗1次,连用4周为1疗程。比较两组临床疗效与药品不良反应。结果:A组腹腔积液治疗完全缓解率18.8%,总有效率90.7%,均明显高于B组(P<0.05)。A组腹痛发生率明显高于B组(P<0.05);两组不良反应总发生率及其余症状发生率比较,无显著差异(P>0.05)。结论:大剂量高聚金葡素注射液联合奥沙利铂腹腔内灌注与大剂量高聚金葡素注射液联合顺铂比较疗效更高,虽腹痛不良反应较明显,但经对症处理后患者均能耐受,可作为治疗恶性腹腔积液有效方法之一。
OBJECTIVE: To observe the clinical efficacy and side effects of high-dose of glucagon injection combined with oxaliplatin and cisplatin peritoneal perfusion in the treatment of malignant ascites. Methods: Sixty patients with malignant ascites were divided into group A (32 cases) and group B (28 cases). In group A, intraperitoneal injection of high-dose glucagon injection combined with oxaliplatin was performed in peritoneal cavity with continuous thin-tube catheter drainage. In group B, intraperitoneal perfusion of high-dose aesculin Injection combined with cisplatin. Treatment once a week, once every 4 weeks for a course of treatment. The clinical efficacy and adverse drug reactions were compared between the two groups. Results: In group A, the complete remission rate and total effective rate were 18.8% and 90.7%, respectively, which were significantly higher than those in group B (P <0.05). The incidence of abdominal pain in group A was significantly higher than that in group B (P <0.05). There was no significant difference between the two groups in the incidence of adverse reactions and the incidence of other symptoms (P> 0.05). Conclusion: High-dose and high-dose of glucagon injection combined with intra-peritoneal infusion of oxaliplatin and high-dose of glucagon injection combined with cisplatin more effective, although adverse reactions were more obvious abdominal pain, but after symptomatic treatment of patients Can tolerate, can be used as an effective treatment of malignant ascites.