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采用放射生物学方法,研究了放射性核素靶向治疗中细胞群大小对EUD和TCP的影响,并以宏观与微观结合的方法,分析了肿瘤中心活性缺失情况下所对应的特征。研究表明,在活性均匀分布的情况下,EUD随细胞群(肿瘤)增大而增大。若考虑细胞间液活性的影响,EUD还会增加约47%。当肿瘤内部活性缺失时,若以TCP=0.90作为衡量标准,周围细胞的211Atα粒子的交叉效应,对于细胞核源最大可弥补边长为4层细胞的肿瘤活性中空,而其它源可弥补边长为6层细胞的肿瘤活性中空。临床治疗中,医师按照模拟结果参考给药时,应参考细胞面源的指导药量,以免由于剂量不足而造成的肿瘤控制的局部失败。TCP可以清晰地表现剂量足与不足时的差异,但是当剂量充足或过量时效果就要差些,因此它比较适合于治疗计划的制定。EUD常用于比较不同活性分布的差异,但用户在使用时一定要注意保持前后模型形状、体积的一致性。
Radiobiology methods were used to study the effects of cell population size on EUD and TCP in targeted therapy of radionuclides. Macroscopical and microscopic methods were used to analyze the corresponding features in the absence of tumor center activity. Studies have shown that in the event of an even distribution of activity, EUD increases with cell population (tumor). Taking into account the effects of intercellular fluid activity, EUD will increase by about 47%. When the tumor activity is absent, if the cross-effect of 211Atα particles in peripheral cells is measured by TCP = 0.90, the maximal active area for the nuclear source can be made to be hollow with 4-layer cells, while the other sources can compensate for the side-length Tumor activity of the 6th layer cells is hollow. Clinical treatment, the physician reference to the simulation results according to the reference should be directed to the cell surface dose, so as to avoid the lack of dose caused by the local failure of tumor control. TCP can clearly show the difference between adequate and insufficient doses, but the effect is worse when the dose is adequate or excessive, so it is more suitable for the treatment plan. EUD is often used to compare the differences in the distribution of different activities, but users must pay attention to maintain the shape of the model before and after the consistency of the volume.