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慢性冠脉阻塞可反应性产生侧枝血管和大量前列腺素。阿斯匹林可阻断环氧合酶而抑制侧枝血管内皮细胞产生前列环素。前列环素具有抗血小板凝聚和扩血管活性。本文通过动物试验以了解阿斯匹林对侧枝循环的影响。 方法 选用成年杂种狗13条,分成二组。甲组狗6条,通过阿斯匹林用前用后的小动脉内花生四烯酸对冠脉血流的影响,确定环氧化酶阻断程度。乙组狗7条,先人为造成
Chronic coronary occlusion reacts to produce collateral vessels and large amounts of prostaglandins. Aspirin blocks cyclooxygenase and inhibits the production of prostacyclin in collateral vessels. Prostacyclin has anti-platelet aggregation and vasodilator activity. This article through animal experiments to understand the impact of aspirin collateral circulation. Methods 13 adult hybrid dogs were selected and divided into two groups. Group A dogs 6, through the aspirin with a small artery before use of arachidonic acid on coronary blood flow to determine the extent of blockade of cyclooxygenase. Group B dog 7, the ancestor is caused