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目的:观察抗磷脂抗体(APA)水平变化及凝血相关指标对抗磷脂综合征(APS)患者易栓症的影响。方法:采用ELISA法检测25例APS患者妊娠各期血清抗心磷脂抗体(ACL)、狼疮样抗凝物、抗β_2糖蛋白Ⅰ抗体表达水平;磁珠法检测纤维蛋白原、D-二聚体、抗凝血酶水平。结果与对照组(我院同期产检无免疫性疾病和血栓病史的健康孕妇)比较。结果:随着孕期增加,APS患者APA、D-二聚体水平均持续增高,至妊娠晚期达到最高(P<0.05);低分子肝素及阿司匹林抗凝治疗后ACL-IgG、ACL-IgM、抗β_2糖蛋白Ⅰ等抗体水平显著下降(P<0.05)。结论:随着妊娠时期持续,APA水平逐渐表达升高,可促进妊娠性易栓症;孕期予以低分子肝素及阿司匹林有助于降低患者APA水平,改善易栓症。
Objective: To observe the changes of antiphospholipid antibody (APA) levels and the influence of coagulation related indexes on thrombophilia in patients with antiphospholipid syndrome (APS). Methods: Serum anti-cardiolipin antibody (ACL), lupus-like anticoagulant and anti-β 2 glycoprotein I antibody levels in 25 APS patients were detected by ELISA. The levels of fibrinogen, D-dimer Antithrombin levels. Results Compared with the control group (healthy pregnant women with no history of immune disease and thrombosis in our hospital during the same period). Results: With the increase of pregnancy, APA and D-dimer levels in APS patients continued to increase until the third trimester of pregnancy (P <0.05). After low molecular weight heparin and aspirin anticoagulation therapy, the levels of ACL-IgG, ACL-IgM, β 2 glycoprotein Ⅰ antibody levels were significantly decreased (P <0.05). CONCLUSIONS: With the continuous development of pregnancy, APA levels gradually increase, which can promote pregnancy-induced thrombosis. Low molecular weight heparin and aspirin during pregnancy help to reduce APA levels and improve thrombophilia.