论文部分内容阅读
研究证实多发性骨髓瘤(MM)存在多种免疫功能缺陷,并对其抗肿瘤免疫应答及免疫治疗产生显著影响,目前仍难以治愈。CD4+CD25+调节性T细胞具有免疫负调控功能,其以一种主动的方式调控机体的免疫应答,对自身抗原和非己抗原均有较强的免疫抑制作用,在肿瘤免疫抑制及免疫逃逸中发挥重要作用,其对MM病程进展、免疫治疗及预后存在显著影响。
Studies have confirmed that multiple myeloma (MM) has multiple immune dysfunction and its anti-tumor immune response and immunotherapy have a significant impact, is still difficult to cure. CD4 + CD25 + regulatory T cells with negative immune regulation function, which in an active way to regulate the body’s immune response to both self-antigen and non-antigen have a strong immune suppression in tumor immunosuppression and immune escape Play an important role, which has a significant impact on the progress of MM, immunotherapy and prognosis.