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目的了解吸入类固醇类药物—二丙酸倍氯米松（必酮碟干粉剂ＢＤＰ）对小儿哮喘的治疗作用及对骨代谢的影响。方法观测ＢＤＰ吸入治疗（＜４００μｇ／ｄ）不同时期患儿肺通气功能，同时用放射免疫分析法测定其血清骨钙素（ＢＧＰ）值。结果２周后小气道功能各指标出现有意义的改善（Ｐ＜００５），治疗２周，３个月，６个月至１年哮喘患儿之ＢＧＰ值经统计学处理无显著意义的下降。结论哮喘患儿之气道阻塞部分可于大气道或小气道，或二者兼有。我国哮喘患儿吸入ＢＤＰ每日剂量在４００μｇ以内是可行的
Objective To investigate the therapeutic effect of inhaled steroid drug beclometasone dipropionate (BCD) on pediatric asthma and its effect on bone metabolism. Methods The pulmonary ventilation function in children with BDP inhalation (<400μg / d) was observed at the same time. Serum BGP was measured by radioimmunoassay. Results After 2 weeks, there was a significant improvement in the indexes of small airway function (P <005). The BGP values of children with asthma at 2 weeks, 3 months, 6 months to 1 year after treatment were statistically insignificant decline. Conclusion Airway obstruction in children with asthma may be in the airway or small airway, or both. In our country asthma children inhaled BDP daily dose of 400μg is feasible