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某些染发剂的组分对果蝇、小鼠淋巴腺瘤细胞和细菌测试系统有诱变性。其中2种成份:4-硝基-邻-苯二胺(4-NOPD)和2-硝基-对苯二胺(2-NPPD),对培养的人类淋巴细胞还有免疫抑制作用并能引起CH3小鼠前列腺细胞形态学上的改变和损害中国田鼠细胞的染色体。作者应用鼠伤寒沙门氏型TA1538菌株进行检测。实验摹拟了人们实际应用染发剂的方式,选用雄性得克萨斯Sprague-Dawley大鼠,将背部毛发剪短,涂受试样品,使其在毛发中保留20分钟,清洗后,每24小时测定一次尿的诱变性,共计4天,受试样品为2种氧化型染发剂染料A染料B及另一种染料C。它们成分相似、只是A、B含有4-NOPD和2-NPPD,C则不含有。作者另用腹腔注入法比
Certain hair dye components are mutagenic to Drosophila, mouse lymphoma cells and bacterial test systems. Two of these components, 4-nitro-o-phenylenediamine (4-NOPD) and 2-nitro-p-phenylenediamine (2-NPPD), also have immunosuppressive effects on cultured human lymphocytes and can cause Morphological changes of prostate cells in CH3 mice and chromosomal damage of Chinese. The authors used Salmonella typhimurium type TA1538 strains for testing. Experiments simulate the way people actually use hair dye, the male Texas Sprague-Dawley rats were selected, the back hair was cut short, coated with the test sample, so that it remains in the hair for 20 minutes, after cleaning, measured once every 24 hours urine For a total of 4 days. The test samples were two oxidative hair dyes, dye A dye B and another dye C. They are similar in composition except that A and B contain 4-NOPD and 2-NPPD, while C does not. The author used another intraperitoneal injection of law than