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目的探讨贝那普利对慢性充血性心衰患者左心室及血管内皮舒张功能的影响。方法 2008年1月至2010年10月收治的符合入选标准的慢性充血性心衰患者216例,依据治疗方法分为常规治疗组106例,贝那普利组110例,观察两组治疗前、后左心室功能及血管内皮舒张功能并进行比较。结果两组在治疗前左心室功能及血管内皮舒张功能比较各检查值无明显差异性。两组治疗后比较左心室功能及血管内皮舒张功能各检查值有统计学差异性。结论贝那普利明显改善左心室功能及血管内皮舒张功能,具有应用方便,顺应性良好,无明显毒副作用可以作为治疗慢性充血性心衰的首选用药。
Objective To investigate the effect of benazepril on left ventricular and vascular endothelial relaxation in patients with chronic congestive heart failure. Methods A total of 216 patients with chronic congestive heart failure who met the inclusion criteria from January 2008 to October 2010 were divided into routine treatment group (106 cases) and benazepril group (110 cases). According to the treatment method, Left ventricular function and vascular endothelial relaxation and compare. Results There was no significant difference between the two groups in the value of left ventricular function and the diastolic function of vascular endothelium before treatment. After treatment, left ventricular function and vascular endothelial relaxation compared with the test values were statistically significant. Conclusions Behenopril can obviously improve left ventricular function and vasodilatory function. It has the advantages of convenient application, good compliance and no obvious side effects. It can be used as the first choice for treating chronic congestive heart failure.