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在正常妊娠时,胎儿肺功能成熟与孕龄有关;另一方面,当妊娠有合并症,由于母体因素,胎儿因素或胎盘情况,使胎儿肺功能成熟可能加速成延迟。本文着重研究在妊娠高血压时如何估计胎儿肺功能成熟,L/S比值与临床结局的关系,以及用L/S比值预测呼吸困难征群的可靠性。在加尔各答医学教育研究所Nehru医院,从92例在妇产科治疗的妊娠高血压患者采集羊水样本,测定磷脂。所获得的数据用卡方试验和t试验进行统计学比较。 92例中属于轻度妊娠高血压者79例(82.6%),重度如妊娠高血压16例(17.4%)。按孕周计算,23例患者有较高的L/S比值超过正常组的范围,表明系胎儿肺功能成熟加速;反之,在37周以后呈现表面活化剂合成显著延迟者有11例。胎儿肺功能成熟
In normal pregnancy, fetal lung function maturity and gestational age; the other hand, when pregnancy complications, due to maternal factors, fetal factors or placental conditions, so that fetal lung function may accelerate into a delayed maturity. This article focuses on how to estimate the fetal lung function maturation in pregnancy-induced hypertension, the relationship between L / S ratio and clinical outcomes, and the reliability of the L / S ratio prediction of dyspnea syndrome. At Nehru Hospital, Calcutta Institute for Medical Education, amniotic fluid samples were collected from 92 patients with gestational hypertension treated in obstetrics and gynecology to determine phospholipids. The data obtained were compared by chi-square test and t-test. Of the 92 cases, 79 (82.6%) were mild-gestational hypertension and 16 were severe cases (17.4%). By gestational age, 23 patients had a higher L / S ratio than the normal group, indicating an accelerated fetal lung function maturity; conversely, there were 11 patients with significant delay in surfactant synthesis beyond 37 weeks. Fetal lung function is mature