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对甲磺酸培氟沙星含量的示波极谱滴定法测定进行了研究。在 pH5 2的HCl NaAc缓冲溶液中 ,四苯硼钠 (Na TPB)与甲磺酸培氟沙星作用可生成 1∶1定量沉淀 ,过滤弃去初滤液 ,用硫酸亚铊标准溶液滴定续滤液中过量的Na TPB ,通过示波极谱图 (dE/dt=f(E)曲线 )上TPB的切口消失指示滴定终点。本法操作简单、快速 ,终点直观 ,应用于多批原料药样品的测定 ,获得了满意的结果 ,其回收率为 99 4 6 %～ 1 0 0 4 % ,相对误差 <± 0 .6 % ,与部颁标准非水滴定法测得的结果基本一致。
The determination of pefloxacin mesylate by oscillopolarographic titration was studied. In pH5 2 HCl NaAc buffer solution, tetraphenylboron sodium (Na TPB) and pefloxacin mesylate effect can produce a quantitative precipitation of 1: 1, filtered to discard the initial filtrate, thallium sulfate titration standard solution titration continued filtrate In excess of Na TPB, the end point of the titration was indicated by the disappearance of the incised TPB on the oscillopolarogram (dE / dt = f (E) curve). The method is simple, rapid, and end-point intuitive and has been applied to the determination of multiple batches of raw drug samples with satisfactory results. The recovery rate is 99 4 6% -1 0 0 4% and the relative error is less than ± 0.6% And Buban standard non-aqueous titration measured results are basically the same.