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盐酸克林霉素主要用于厌氧菌引起的腹腔和妇科感染。现有注射剂、胶囊等制剂。我们研制的盐酸克林霉素栓剂,经妇产科临床应用,表明对细菌性阴道疾病有明显的疗效。1 仪器与试剂 岛津LC-6A高效液相色谱仪;AE-260型电子分析天平;盐酸克林霉素原料(湖北宜药集团提供);36号半合成脂肪酸甘油酯(广州市化学试制厂);其他试剂均为分析纯2 制备2.1 处方 盐酸克林霉素300g,36号半合成脂肪酸甘油酯适量,共制成1000粒2.2 制法 取36号半合成脂肪酸甘油酯,置水浴上加热熔
Clindamycin hydrochloride is mainly used for anaerobic bacteria caused by abdominal and gynecological infections. Existing injection, capsules and other preparations. We developed clindamycin hydrochloride suppository, obstetrics and gynecology clinical application, showed that bacterial vaginosis have significant effect. 1 instruments and reagents Shimadzu LC-6A high performance liquid chromatography; AE-260 electronic analytical balance; clindamycin hydrochloride raw materials (Hubei Yiwu Group); 36 semi-synthetic fatty acid glycerides (Guangzhou Chemical Plant ); Other reagents are of analytical grade 2 Preparation 2.1 Prescription Clindamycin Hydrochloride 300g, 36 semi-synthetic fatty acid glycerides appropriate, a total of 1000 made 2.2 Preparation method 36 semi-synthetic fatty acid glycerides, placed in water bath on the melt