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本文经Q带分析额外21号染色体来源,并用核仁组织区银染法与G显带(Ag-NOR-G)复合技术判断随体联合(Ag-AA),对22例21三体综合征患儿及其父母的近端着丝粒染色体随体联合频率与染色体不分离的关系进行了研究。结果表明:发生不分离的父或母方与44名正常人比较Ag-AA频率在20～42岁年龄组间及性别间均无显著性差异。各近端着丝粒染色体参与Ag-AA的倾向基本一致。从本组的研究中,没有证据表明21三体征患儿父母的染色体不分离与Ag-AA频率增高有关。
In this paper, Q chromosome was used to analyze the extra chromosome 21 source, and Ag-NOR-G combined with Ag-NOR was used to determine the association of 22 trisomy 21 The relationship between the frequency of the satellite centromeric chromosomes and the non-segregation of chromosomes in children and their parents was studied. The results showed that there was no significant difference in the frequency of Ag-AA between the age groups of 20-42 and the gender between 44 and non-separated parents or males. The propensity of each centromeric chromosome to participate in Ag-AA was basically the same. From this study, there is no evidence that chromosome segregation of parents in trisomy 21 correlated with increased Ag-AA frequency.