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The fruits of Paulownia catalpifolia Gong Tong are used as a Chinese folk herbal medicine for the treatment of enteritis,tonsillitis,bronchitis,and dysentery,etc.Our previous study has identified new C-geranylated flavanones with obvious anti-proliferative effects in lung cancer A549 cells.In the present study,a new C-geranylated flavone,paucatalinone C (1) and five known C-geranylated flavanones (2-6) were isolated.In addition,a total of 34 C-geranylated flavonoids were detected by HPLC-DAD-ESI-MS/MS coupling techniques from the CH2C12 extract of P catalpifolia.Futhermore,anti-aging effects of isolated compounds were evaluated in vitro with premature senescent 2BS cells induced by H2O2.Phytochemical results indicated that P.catalpifolia was a natural resource of abundant C-geranylated flavonoids.Diplacone (3) and paucatalinone A (5) were the potent anti-aging agents in the premature senescent 2BS cells induced by H2O2 and the C-geranyl substituent may be an important factor because of its lipophilic character.