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目的:了解我院药品不良反应(ADR)的发生规律及特点,促进临床合理用药。方法:对我院2007～2010年上报的ADR建立Excel表格,按照患者性别、年龄、给药途径、原患疾病、药品种类、累及器官及临床表现等进行统计分析。结果:963例ADR中男597例(61.99%),女366例(38.01%);抗感染药物引起的ADR比例最高,有571例(59.29%),尤其以头孢菌素类药物最为多见;ADR主要临床表现为皮肤和消化系统损害。结论:医院应重视临床药物的合理使用,加强ADR的监测,减少ADR的发生。
Objective: To understand the rules and characteristics of Adverse Drug Reaction (ADR) in our hospital and to promote clinical rational use of drugs. Methods: An Excel spreadsheet was established for ADRs reported in our hospital from 2007 to 2010 and statistically analyzed according to patient’s sex, age, route of administration, original disease, drug type, organ involved and clinical manifestations. Results: Among 963 ADRs, 597 (61.99%) were male and 366 (38.01%) were female. The highest ADR was caused by antiinfective drugs (571 cases, 59.29%), especially cephalosporins. The main clinical manifestations of ADR are skin and digestive system damage. Conclusion: The hospital should pay attention to the rational use of clinical drugs, strengthen the monitoring of ADR and reduce the occurrence of ADR.