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目的:通过观察多索茶碱联合氨茶碱治疗慢性阻塞性肺炎患者的临床效果,评价两种治疗方法的临床优势。方法:选取于2013年1月到2016年4月在我院接受治疗的慢性阻塞性肺炎患者64例作为研究对象,随机分为对照组和实验组各32例,其中对照组患者给予常规药物氨茶碱进行治疗,实验组患者采用氨茶碱联合多索茶碱进行治疗。治疗期间观察两组患者的治疗有效情况以及出现的不良反应,并进行比较。结果:对照组患者总体有效率为81.25%(有效16例、显效10、无效5例);实验组患者总体有效率达93.75%(有效19例、显效11、无效2例)。实验组和对照组相比具有统计学意义(P<0.05)。对照组不良反应发生率为46.87%(恶心5例、心悸4例、失眠6例);实验组不良反应率为15.62%(恶心2例、心悸1例、失眠2例)。两组间存在显著性差异(P<0.05)。结论:治疗慢性阻塞性肺炎时,多索茶碱联合氨茶碱治疗方案临床效果优于氨茶碱,能使患者的有效率提高和不良反应降低。
OBJECTIVE: To evaluate the clinical advantages of both therapies by observing the clinical efficacy of doxofylline combined with aminophylline in the treatment of patients with chronic obstructive pulmonary disease. Methods: Sixty-four patients with chronic obstructive pulmonary disease who were treated in our hospital from January 2013 to April 2016 were selected and randomly divided into control group and experimental group, with 32 cases in each. Patients in the control group were given routine drug ammonia Theophylline was treated with aminophylline and doxofylline in the experimental group. During the treatment of two groups of patients observed the treatment of effective and adverse reactions, and compared. Results: The overall effective rate of the control group was 81.25% (effective 16 cases, markedly effective 10, ineffective 5 cases). The overall effective rate of the experimental group was 93.75% (effective 19 cases, markedly effective 11, ineffective 2 cases). The experimental group and the control group was statistically significant (P <0.05). The incidence of adverse reactions in the control group was 46.87% (nausea in 5 cases, palpitations in 4 cases and insomnia in 6 cases). The adverse reaction rate in the experimental group was 15.62% (nausea in 2 cases, palpitations in 1 case, insomnia in 2 cases). There was a significant difference between the two groups (P <0.05). Conclusion: The treatment effect of doxofylline combined with aminophylline is superior to aminophylline in the treatment of chronic obstructive pulmonary disease, which can improve the patients’ efficiency and reduce the adverse reactions.