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目的:调查依替米星联用其他抗菌药对老年重症肺炎患者肾功能的影响。方法:对47例依替米星联用其他抗菌药治疗的老年重症肺炎患者进行回顾性分析。47例老年患者中,32例为60～79岁,15例>80岁,观察患者治疗前后血清肌酐(Scr)、血尿素氮(BUN)及尿蛋白变化情况,计算内生肌酐清除率(Ccr)。结果:47例患者在依替米星治疗前,Scr、BUN、Ccr均值分别为106±26.5μmol/L、6.3±2.9mmol/L、44±14ml/min;用药后Scr、BUN均值分别下降为97±17.7μmol/L和5.4±2.6mmol/L,Ccr均值升高为46±13ml/min。但治疗前后的这些数据差异无统计学意义(P>0.05)。患者的尿蛋白明显下降(P<0.01)。结论:依替米星联用其他抗菌药治疗老年重症肺炎患者未见明显肾毒性,是一种较为安全的疗法。
Objective: To investigate the effect of etimicin combined with other antibacterials on renal function in elderly patients with severe pneumonia. Methods: A retrospective analysis was performed on 47 elderly patients with severe pneumonia treated with etimicin plus other antibacterials. Of the 47 elderly patients, 32 were 60-79 years old and 15 were> 80 years old. The changes of serum creatinine (Scr), blood urea nitrogen (BUN) and urinary protein before and after treatment were observed. Endogenous creatinine clearance (Ccr ). Results: The mean Scr, BUN and Ccr of 47 patients before treatment with etimicin were 106 ± 26.5μmol / L, 6.3 ± 2.9mmol / L and 44 ± 14ml / min, respectively. After treatment, the average values of Scr and BUN decreased to 97 ± 17.7μmol / L and 5.4 ± 2.6mmol / L, the mean Ccr increased to 46 ± 13ml / min. However, these data before and after treatment showed no significant difference (P> 0.05). Patients’ urinary protein decreased significantly (P <0.01). Conclusion: Etimicin combined with other antimicrobial agents in the treatment of elderly patients with severe pneumonia showed no significant renal toxicity, is a safer therapy.