Heme oxygenase-1 protects donor livers from ischemia/reperfusion injury:The role of Kupffer cells

• 作 者: Zeng Zhong Huang Han-Fei Che
• 机 构: KunmingMedColl,ThirdMilMedUniv
• 出 处: 世界胃肠病学杂志：英文版（电子版）
• 发表日期: 2010年10期
• 基金项目: Supported by The Natural Science Foundation of Yunnan Province,China, No.2007C137M,, the Joint Funds of Natural Science Foundation of Yunnan Province,China,No.2007C0009R

AIM:To examine whether heme oxygenase (HO)-1 overexpression would exert direct or indirect effects on Kupffer cells activation, which lead to aggravation of reperfusion injury.METHODS: Donors were pretreated with cobalt protoporphyrin (CoPP) or zinc proto