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目的探讨脂质体包裹的5-氟尿嘧啶对兔耳增生性瘢痕组织的透皮吸收能力。方法在兔耳增生性瘢痕模型上进行透皮扩散,比较5-氟尿嘧啶脂质体及其普通凝胶剂对瘢痕皮肤的渗透能力。结果在体瘢痕透皮试验12h后,脂质体组瘢痕组织中的5-氟尿嘧啶单位面积透皮药量显著高于普通凝胶剂组(234.57±56.25)μg.cm-2和(45.24±9.38)μg.cm-2,P<0.01。结论在体瘢痕组织透皮试验中,脂质体剂型优于普通凝胶剂型促进5-氟尿嘧啶透皮的能力。
Objective To investigate the transdermal absorbability of liposome-encapsulated 5-fluorouracil on hypertrophic scar in rabbit ear. Methods Percutaneous transdermal proliferation was performed on a rabbit model of hypertrophic scars of rabbit ear. The penetrating ability of 5-fluorouracil liposomes and its common gels on scar skin was compared. Results The transdermal dosage of 5-fluorouracil per unit area in the scar tissue of the liposome group was significantly higher than that of the conventional gel group (234.57 ± 56.25 μg · cm-2 and (45.24 ± 9.38 ) μg.cm-2, P <0.01. Conclusion In the dermal penetration test, the liposomal dosage form is better than the common gel dosage form to promote the transdermal delivery of 5-fluorouracil.