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生物素化物酶(Bitinidase EC3、5、1、12)是一种酰氨基水解酶,能从生物胞素或生物素肽分子上将生物素裂解下来。它在血清、肝、肾和肾上腺中含量丰富,但在脑中含量较低。作者测定了21例包括乙型肝炎和酒精性肝硬化在内的慢性肝病患者的生物素化物酶活性,并同时测定其血清白蛋白含量。经肝组织活检证实,他们均患有肝硬化,但尚无蛋白尿。结果表明:正常成年人生物素化物酶活性为7.1u/L,范围4.4—10.1u/L,而所有患者的该酶活性范围则在0.5～8.0u/L,其中13例低于4.4u/L。患者的血清生物素化物酶活性与白蛋白浓度呈正相关(r=0.87)。因为白蛋白几乎完全是由肝脏合成并分泌到血流中,患肝硬化时,白蛋白的合成减少,上述
Bitinidase EC3,5,1,12 is an amidohydrolase that cleaves biotin from biotin or biotin peptide molecules. It is abundant in serum, liver, kidney and adrenal glands, but it is low in the brain. The authors measured the biotinidase activity in 21 patients with chronic liver disease, including hepatitis B and alcoholic cirrhosis, and determined serum albumin levels at the same time. Liver biopsy confirmed that they all had cirrhosis, but no proteinuria. The results showed that the activity of biotin in normal adults was 7.1u / L, ranging from 4.4-10.1u / L, while the activity of all patients was 0.5 ~ 8.0u / L, of which 13 were lower than 4.4u / L. The patient’s serum biotin enzyme activity and albumin concentration was positively correlated (r = 0.87). Since albumin is almost completely synthesized by the liver and secreted into the bloodstream, the synthesis of albumin is reduced when suffering from cirrhosis,