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目的观察GP方案治疗手术后局部复发或肺内转移非小细胞肺癌的疗效及毒性反应。方法对48例手术后局部复发或肺内转移病例应用GP方案化疗,给药方法:吉西他滨1000mg/m2,第1、8、15天,静脉点滴:DDP 20 mg,第1~5天,静脉点滴,28 d为一个周期,均常规化疗4个周期以上。结果CR 4例(鳞癌),PR 23例(其中鳞癌9例,腺癌14例),NC 14例,PD 5例,总有效率56.2%(其中鳞癌40.7%,腺癌76.2%)。局部复发病灶有效率58.3%(7/12),肺内多发转移结节可测病灶共238处,有效率63.9%(152/238)。结论GP方案对晚期及术后复发、转移NSCLC疗效满意,毒副反应可以耐受。
Objective To observe the efficacy and toxicity of GP regimen in the treatment of local recurrence or intrapulmonary metastasis of non-small cell lung cancer. Methods 48 cases of local recurrence or intrapulmonary metastasis after the application of GP regimen chemotherapy, administration methods: Gemcitabine 1000mg / m2, the first 1,8,15 days, intravenous drip: DDP 20 mg, 1 to 5 days, intravenous drip , 28 d for a cycle, are more than 4 cycles of conventional chemotherapy. Results There were 4 cases of squamous cell carcinoma, 23 cases of squamous cell carcinoma, 9 cases of squamous cell carcinoma, 14 cases of adenocarcinoma, 14 cases of NC and 5 cases of PD. The total effective rate was 56.2% (40.7% in squamous cell carcinoma and 76.2% in adenocarcinoma) . The effective rate of local recurrence was 58.3% (7/12). There were 238 measurable lesions in the lung with multiple metastatic nodules, with an effective rate of 63.9% (152/238). Conclusion GP regimen is effective in treating advanced and postoperative recurrence and metastasis of NSCLC, and its toxicity can be tolerated.