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目的:采用高效液相色谱法测定盐酸普萘洛尔片的含量。方法:Diamonsil C18柱(4．6 mm×150 mm,5 μm)为分析柱,流动相为甲醇-0.02 mol·L-1磷酸二氢钾溶液(50:50),流速0．9 ml·min-1,检测波长290 nm。结果:盐酸普萘洛尔在50．7 -405．9 μg·ml-1范围内呈良好的线性关系,r=0．999 9,平均回收率为99．2％,RSD=0．92％(n=9)。结论:本方法简单、快速、结果可靠。
Objective: To determine the content of propranolol hydrochloride tablets by high performance liquid chromatography. Methods: Diamonsil C18 column (4.6 mm × 150 mm, 5 μm) was used as the analytical column. The mobile phase consisted of methanol-0.02 mol·L-1 potassium dihydrogen phosphate solution (50:50) and the flow rate was 0.9 ml · min -1, detection wavelength 290 nm. Results: Propranolol hydrochloride had a good linear relationship in the range of 50.7-405.9 μg · ml-1, r = 0.999 9, with an average recovery of 99.2% and a RSD of 0.92% (n = 9). Conclusion: The method is simple, rapid and reliable.