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目的综合分析白细胞介素(IL)1A基因rs3783553单核苷酸多态性与中国汉族人群癌症易感性的关系。方法检索Pubmed、Springer、EMBASE以及中国知网、万方和生物医学文献数据库,检索有关IL-1A基因rs3783553位点多态性与癌症易感性的病例对照研究,利用STATA12.0软件行Meta分析,并进一步行亚组分析、敏感性分析及发表偏倚检测。结果本研究共纳入14篇文献,共计12 369例研究对象,其中癌症患者5 708例,健康对照者6 661例。Meta分析结果显示,等位基因模型I vs.D(OR=0.82,95%CI:0.75~0.89)、纯合子模型II vs.DD(OR=0.62,95%CI:0.55~0.70)、杂合子模型ID vs.DD(OR=0.86,95%CI:0.80~0.93)、隐性基因模型II vs.ID/DD(OR=0.68,95%CI:0.60~0.76)以及显性基因模型II/ID vs.DD(OR=0.81,95%CI:0.75~0.87)中各基因型的癌症易感性差异均存在统计学意义(P均<0.05)。亚组分析结果显示,该基因位点多态性可能与我国汉族人群罹患消化系统恶性肿瘤以及女性罹患生殖系统癌症的风险降低有关。结论 IL-1A基因rs3783553多态性与中国汉族人口癌症易感性相关,其中I等位基因可能是中国汉族人群的保护因素,而等位基因D则可能是其癌症易感因素。
Objective To analyze the relationship between rs3783553 single nucleotide polymorphism of interleukin (IL) 1A gene and susceptibility to cancer in Chinese Han population. Methods Pubmed, Springer, EMBASE, CNKI, Wanfang and biomedical literature databases were searched to search for case-control study on rs3783553 polymorphism of IL-1A gene and susceptibility to cancer. Meta-analysis was performed using STATA12.0 software, Further subgroup analysis, sensitivity analysis and publication bias test. Results A total of 14 articles were included in the study, totaling 12,369 subjects, including 5 708 cancer patients and 6 661 healthy controls. Meta-analysis showed that allele model I vs. D (OR = 0.82, 95% CI: 0.75-0.89), homozygous model II vs. DD (OR = 0.62, 95% CI: 0.55-0.70) Model ID vs. DD (OR = 0.86, 95% CI: 0.80 to 0.93), recessive gene model II vs. ID / DD (OR = 0.68, 95% CI: 0.60 to 0.76), and dominant gene model II / ID There were significant differences in the susceptibility to cancer among all the genotypes (P <0.05) vs.DD (OR = 0.81, 95% CI: 0.75-0.87). Subgroup analysis showed that the polymorphism of this locus may be related to the risk of digestive system malignant tumors and female cancers of reproductive system in Chinese Han population. Conclusion The rs3783553 polymorphism of IL-1A gene is associated with cancer susceptibility in Chinese Han population. The I allele may be the protective factor in Chinese Han population, and the allele D may be the predisposing factor of cancer.