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目的观察甲氨蝶呤(MTX)联合米非司酮连续用药保守治疗异位妊娠的疗效及安全性。方法将125例患者随机分成两组,观察组68例,采用MTX联合米非司酮连续5日用药保守治疗;对照组57例,采用MTX连续5日用药保守治疗。结果观察组治愈67例(98.5%)。临床症状消失时间(9.23±3.12)d;血HCG恢复正常时间(14.12±3.22)d;B超:妊娠“包块”消失时间是(90.33±9.21)d。对照组治愈47例(82.46%)。临床症状消失时间(13.21±2.65)d;血HCG恢复正常时间(27.25±4.61)d;B超:妊娠“包块”消失时间是(110.63±8.27)d。两组比较治愈率、临床症状消失时间、血HCG恢复正常时间、B超:妊娠“包块”消失时间均有统计学意义(P<0.05)。结论 MTX联合米非司酮用于异位妊娠的保守治疗高效、安全。
Objective To observe the efficacy and safety of methotrexate (MTX) combined with mifepristone in conservative treatment of ectopic pregnancy. Methods 125 patients were randomly divided into two groups, the observation group 68 cases, the use of MTX combined with mifepristone 5 consecutive days of conservative treatment; control group 57 cases, the use of MTX for 5 consecutive days of conservative treatment. Results The observation group cured 67 cases (98.5%). The clinical symptoms disappeared (9.23 ± 3.12) d, the time of HCG recovery was (14.12 ± 3.22) d, and B was (90.33 ± 9.21) d in pregnancy. The control group was cured in 47 cases (82.46%). The disappearance time of clinical symptoms was (13.21 ± 2.65) d, the time of returning normal blood HCG was (27.25 ± 4.61) d, and the time of disappearance of “B” was (110.63 ± 8.27) days. The two groups were compared cure rate, clinical symptoms disappear time, blood HCG recovery time, B ultrasound: pregnancy, “mass” disappear time was statistically significant (P <0.05). Conclusion MTX combined with mifepristone for the conservative treatment of ectopic pregnancy efficient and safe.