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1985年Hirai通过NIH/3T3细胞转染分析,研究了8例慢性粒细胞白血病(CML),报告一例发生N-ras基因突变。随后Janss-en等应用聚合酶链式反应(PCR)技术,进行35例CML研究,得出相反的结果。而Liu等采用同样技术在所研究的12个病人中发现4例ras突变,4例中3例发生在急变期。为
In 1985 Hirai analyzed 8 cases of chronic myelogenous leukemia (CML) by NIH/3T3 cell transfection analysis and reported a case of N-ras gene mutation. Then Janss-en et al. used polymerase chain reaction (PCR) technology to perform 35 CML studies and obtained the opposite result. However, Liu et al. used the same technique to find 4 cases of ras mutation in the 12 patients studied, and 3 of 4 cases occurred in blast crisis. for