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选择5名27-36岁母亲,于产后第三天早晨(禁食10小时后),口服1.5 mg氟化钠水溶液。服食前及服后30、60、90和120分钟时同时采集血和人乳样品。血浆氟含量用灵敏的电极法测定,人乳氟含量测定用改良微量扩散法。结果口服氟后,血浆氟含量均迅速升高,由服前的约10～15 ng/ml升至服后30分钟的70～86 ng/ml;以后即缓慢下降,直至120分钟仍维持在50 ng/ml左右;而人乳的氟含量则未见相应升高,服氟前后始终在2～8 ng/ml之间。本调查采集受试母亲的血浆和人乳的时间均达服氟后二小时之久,因在另一次调查中表明人乳氟含量一直恒定,故可排除氟延缓转移
Five mothers aged 27-36 years were enrolled and 1.5 mg of sodium fluoride aqueous solution was orally administered on the third morning after delivery (after 10 hours of fasting). Blood and human milk samples were collected simultaneously at 30, 60, 90 and 120 minutes before and after serving. Determination of plasma fluoride content by sensitive electrode method, Determination of human milk fluorine content with a modified trace diffusion method. Results After oral administration of fluoride, the plasma fluorine content increased rapidly from about 10 ~ 15 ng / ml in pre-service to 70 ~ 86 ng / ml in 30 minutes post-administration; then slowly decreased until 50 minutes after 120 minutes ng / ml or so, while the fluorine content of human milk did not increase correspondingly, before and after serving fluoride always between 2 ~ 8 ng / ml. The survey collected plasma and human milk of test mothers for two hours after reaching fluoride, because in another survey showed that the content of human milk fluorine has been constant, it can rule out the transfer of fluorine delay