Expression and sub-cellular localization of leucine-rich repeats and immunoglobulin-like domains are

• 作 者: Okechi Humphrey
• 机 构: Department of Neurosurgery, Renmin Hospital of Wuhan University,
• 出 处: Neural Regeneration Research
• 发表日期: 2011年11期
• 关键词: immunoglobulin cytoplasmic repeats thioredoxin glutamate subunit cysteine ligase

The current study investigated correlations between the expression of leucine-rich repeats and immunoglobulin-like domain 1 (LRIG1) and antioxidant enzymes and related proteins, including manganese superoxide dismutase, glutamate cysteine ligase catalytic or regulatory subunit, thioredoxin and thioredoxin reductase, in both human ependymoma and oligodendroglioma. Results revealed that the cytoplasmic expression of LRIG1 was associated with expression of glutamate cysteine ligase catalytic subunit in the human ependymoma, while the nuclear expression of LRIG1 was associated with expression of thioredoxin reductase. In human oligodendroglioma, the cytoplasmic expression of LRIG1 was associated with expression of the glutamate cysteine ligase catalytic subunit. Both the nuclear and perinuclear expressions of LRIG1 were associated with expression of glutamate cysteine ligase regulatory subunit. These results indicated that several antioxidant enzymes and related proteins contributed to LRIG1 expression, and that these may participate in the antioxidation of the cells.

The current study investigated correlations between the expression of leucine-rich repeats and immunoglobulin-like domain 1 (LRIG1) and antioxidant enzymes and related proteins, including manganese superoxide dismutase, glutamate cysteine ​​ligase catalytic or regulatory subunit, thioredoxin and thioredoxin reductase, in both human Results showed that the cytoplasmic expression of LRIG1 was associated with expression of glutamate cysteine ​​ligase catalytic subunit in the human ependymoma, while the nuclear expression of LRIG1 was associated with expression of thioredoxin reductase. In human oligodendroglioma, the cytoplasmic expression of LRIG1 was associated with expression of the glutamate cysteine ​​ligase catalytic subunit. Both the nuclear and perinuclear expressions of LRIG1 were associated with expression of glutamate cysteine ​​ligase regulatory subunit. These results indicate that several antioxidant enzymes and related proteins contributed to LRI G1 expression, and that these may participate in the antioxidation of the cells.