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肿瘤患者免疫功能是否降低,目前还存在不同的见解,Harris 指出肿瘤患者即使保持免疫功能,肿瘤还是持续增殖;倘若免疫功能降低,有时仍维持缓解现象。故认为免疫力升降与肿瘤消长不是直接关系。但从临床症状及预后观察,免疫力正常,生存率往往延长。在一般情况下,肿瘤患者后期,由于代谢异常,改变了免疫调节,出现免疫功能障碍,引起细胞免疫功能降低,导致肿瘤恶性发展。但其淋巴细胞体外功能测定往往与正常淋巴细胞没有显著性差异,这是由于患者血清中存在抑制因子,或检测方法不敏感所致。
There are still different opinions about whether immune function of tumor patients is reduced. Harris pointed out that tumor patients continue to proliferate even if they maintain immune function. In some cases, if the immune function is reduced, they may still maintain the remission. Therefore, the rise and fall of immunity is not directly related to tumor growth and decline. However, clinical symptoms and prognosis, normal immunity, survival rates are often extended. In general, patients with advanced cancer, due to metabolic abnormalities, changed the immune regulation, immune dysfunction, causing reduced cellular immunity, leading to malignant tumor. However, the in vitro function of lymphocytes is often not significantly different from that of normal lymphocytes, which is due to the presence of inhibitors in the serum of patients or the insensitivity of detection methods.