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1986年9月,我们观察了不同剂量乙肝疫苗的免疫学效果,以期探讨小剂量乙肝疫苗接种的问题,结果如下。疫苗为卫生部北京生物制品研究所生产的859—1、2、5、10批。1986年9月按随机的原则选择沈阳市2个幼儿园及1个产科病房,年龄自出生到学龄前儿童,从中抽取一定量人群为预选对象,筛选无肝病史,SGPT 值正常,HBV感染标志全部阴性儿童为观察对象。免疫后资料完整可统计的共465人,后分成5个不同剂量组:甲组为2.5μg/ml,乙组为4μg/ml,丙组为5μg/ml,丁组为6μg/ml,戊组为10μg/ml,
In September 1986, we observed the immunological effects of different doses of hepatitis B vaccine in order to explore the issue of low-dose hepatitis B vaccination, the results are as follows. Vaccine for the Ministry of Health Beijing Institute of Biological Products 859-1,2,5,10 batch. In September 1986, two kindergartens and one maternity ward in Shenyang were chosen according to the principle of randomness. A group of obese children were born from premature to pre-school age. A certain amount of people were selected as the pre-selected target. The history of non-liver disease was screened, SGPT value was normal and all signs of HBV infection Negative children were observed. After immunization, a total of 465 individuals could be statistically analyzed, and then divided into 5 different dose groups: 2.5μg / ml in group A, 4μg / ml in group B, 5μg / ml in group C and 6μg / ml in group D, 10 μg / ml,