论文部分内容阅读
热休克蛋白(Hsp)是Ritossa最先在果蝇唾液腺中发现的遗传高度保守的热应激蛋白质家族,又称应激蛋白。其广泛存在于多种生物细胞中,作为分子伴侣(分子伴侣是指在体内帮助其他含多肽的物质正确组装,但不参与其生物学作用),当遭受氧化应激、高热、缺血等应激时,在蛋白质内稳态、凋亡、侵袭、细胞信号转导中扮演重要角色~([1])。基于氨基酸序列和分子量大小,Hsp可分5个家族。Hsp27,鼠类为Hsp25,属于小分子量Hsp家族中的重要成员,普遍存在于
Heat shock protein (Hsp) is Ritossa first in the Drosophila salivary glands found in genetically highly conserved heat-stress protein family, also known as stress proteins. It exists widely in a variety of biological cells as molecular chaperones (chaperones refer to the correct assembly of other peptide-containing substances in the body but not involved in their biological role), when subjected to oxidative stress, hyperthermia, ischemia, etc. When excited, it plays an important role in protein homeostasis, apoptosis, invasion and cell signal transduction ([1]). Based on the amino acid sequence and molecular size, Hsp can be divided into five families. Hsp27, a murine Hsp25, is an important member of the small molecular weight Hsp family and is commonly found in