Antibiotic sensitivity pattern of bacterial pathogens in the intensive care unit of Fatmawati Hospit

• 作 者: Maksum Radji Siti Fauziah Nurgani Aribinuko
• 机 构: Laboratory of Microbiology and Biotechnology, Department of Pharmacy, Faculty of Mathematics and Sci
• 出 处: 亚太热带生物医学杂志（英文版）
• 发表日期: 2011年1期
• 关键词: Antibiotic susceptibility Intensive care unit Bacterial resistance Bacterial pat

Objective: To evaluate the sensitivity patt of bacterial pathogens in the intensive care unit (ICU) of a tertiary care of Fatmawati Hospital Jakarta Indonesia. Methods: A cross sectional retrospective study of bacterial pathogen was carried out on a total of 722 patients that were admitted to the ICU of Fatmawati Hospital Jakarta Indonesia during January 2009 to March 2010. All bacteria were identified by standard microbiologic methods, and their antibiotic susceptibility testing was performed using disk diffusion method. Results: Specimens were collected from 385 patients who were given antimicrobial treatment, of which 249 (64.68%) were cultured positive and 136 (35.32%) were negative. The most predominant isolate was Pseudomonas aeruginosa (P. aeruginosa) (26.5%) followed by Klebsiella pneumoniae (K. pneumoniae) (15.3%) and Staphylococcus epidermidis (14.9%). P. aeruginosa isolates showed high rate of resistance to cephalexin (95.3%), cefotaxime (64.1%), and ceftriaxone (60.9%). Amikacin was the most effective (84.4%) antibiotic against P. aeruginosa followed by imipenem (81.2%), and meropenem (75.0%). K. pneumoniae showed resistance to cephalexin (86.5%), ceftriaxone (75.7%), ceftazidime (73.0%), cefpirome (73.0%) and cefotaxime (67.9%), respectively. Conclusions: Most bacteria isolated from ICU of Fatmawati Hospital Jakarta Indonesia were resistant to the third generation of cephalosporins, and quinolone antibiotics. Regular surveillance of antibiotic susceptibility patts is very important for setting orders to guide the clinician in choosing empirical or directed therapy of infected patients.