The effect of Chinese herbal medicine“heche assisted pregnancy recipe”on endometrial estrogen and pr

• 作 者: 刘效群 阚国英 彭玉梅 樊瑞琴 齐惠敏 焦妹芬 李忠 石彬
• 机 构: Hebei Research Institute for Family Planning,Department of Gynecology & Obstetrics
• 出 处: 生殖医学杂志
• 发表日期: 2004年期
• 关键词: Heche assisted pregnancy recipe Infertility Endometrium Receptor estrogen Recept

Objectives:To investigate the effect of Chinese herbal medicine"heche assisted preg-nancy recipe (HCAPR)" on estrogen receptor(ER), progesterone receptor (PR), pro-lifierating cell nuclear antigen(PCNA) and vascular endothelial growth factor (VEGF)in endometrium of infertile women.Methods: The S-P immunohistochemical assay was used to observe expression ofER, PR , PCNA and VEGF in late proliferative phase before and after the HCAPR treat-ment.Results: After the treatment, the expression of ER,PR,PCNA and VEGF in nucleiof glandular epithelium and stromal cells was significantly stronger (all P＜0. 001) re-spectively than that before treatment , especially the expression of PCNA and VEGF.Conclusions: These results suggest that traditional Chinese medicine HCAPR oftonifying kidney and regulating menstruation increased the synthesis of ER,PR, PCNAand VEGF, which may promote normal growth and development of the endometrium ,improve the micro-environment of the endometrium, and enhance uterine receptivity.The evidence may provide theoretical basis for therapy infertility with Chinese herbalmedicine.