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目的:研究新疆维吾尔族;土尔扈特蒙古族;汉族健康人群血管紧张素转换酶(ACE)基因插入?缺失多态性分布情况。方法:采用PCR技术,分别对新疆地区维吾尔族;吐尔扈特蒙古族;汉族健康人群作ACE I/D基因型检测,分类计数进行统计学处理。结果:维吾尔族正常人群ACE水平以DD基因型频率最高(46.3%)(χ2=14.6,P(0.005);土尔扈特蒙古族人群以Ⅱ基因频率最高(48.78%)(χ2=13.77;P(0.005);汉族人群以DI型基因频率最高(46.2%)(χ2=13.77;P(0.005)。结论:ACE基因多态性分布种族之间存在差异,种族内等位基因型效率分布男女间无显著性差异(χ2=0.0960,P>0.05)。
Objective: To investigate the distribution of angiotensin converting enzyme (ACE) gene insertion and deletion polymorphism in Xinjiang Uygur and Tuerut Mongolian. Methods: PCR-based methods were used to detect the ACE I / D genotypes of Uygur, Torghut Mongolian and Han healthy population in Xinjiang, respectively. Results: The frequency of genotype Ⅱ was the highest (46.3%) in Uygur normal subjects (χ2 = 14.6, P <0.005). The frequency of genotype Ⅱ in Tuerhut Mongol population was the highest (48.78%) (0.005). The frequency of DI genotype was the highest in Han nationality (46.2%) (χ2 = 13.77; P (0.005) .Conclusion: There were differences in distribution of polymorphism of ACE gene between races and genotypes No significant difference (χ2 = 0.0960, P> 0.05).