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用淋巴细胞转化现象作为指标来探讨药疹,必须适当地并用免疫载体,这是因为药物本身常为半抗原。通常在试管内观察淋巴细胞转化现象,用患者的血清作为载体,但药物变态反应不仅出现皮疹,亦可发生在多种器官,故推测各器官可能存在特有的载体。在药疹的情况下,药物可能与特定的皮肤组织部分相结合,使半抗原的药物获得抗原性。作者为了探讨药疹的淋巴细胞转化现象,对固定性药疹7例、麻疹样及多形红斑样药疹8例共15例患者进行了研究。这些病例的过敏药物有氯霉素、四
Using the phenomenon of lymphocyte transformation as an index to explore drug eruptions, the immunological carrier must be used properly, because the drug itself is often a hapten. Usually observed in vitro test of lymphocyte transformation, with the patient’s serum as a carrier, but the drug allergy not only rash can also occur in a variety of organs, it is speculated that each organ may exist unique vector. In the case of drug eruptions, the drug may bind to specific parts of the skin tissue, rendering the hapten’s drug antigenic. In order to explore the phenomenon of lymphocyte transformation of drug eruption, the authors studied in seven cases of fixed drug eruption, 8 cases of measles-like and erythema multiforme-like drug eruptions. Allergic drugs in these cases have chloramphenicol, four