论文部分内容阅读
目的了解双环醇片治疗儿童肝炎的疗效和安全性,为临床医师提供理论依据和用药方法。方法采用随机、对照、开放性临床研究,对148例轻、中度慢性乙型、丙型肝炎患儿随机分成试验组和对照组(75∶73),分别用双环醇片和护肝片治疗,两组疗程均为12周。观察治疗前、后4周、8周、12周血常规、尿常规、ALT、AST,同时观察一般状况及相关症状、体征。结果(1)治疗组ALT和AST水平较对照组降低更为显著,且治疗12周疗效优于治疗4周和8周(P<0.01);(2)治疗组的有效率较对照组更为显著(P<0.01),且两组12周的有效率均优于4周和8周;(3)治疗组改善肝病相关症状更为显著(P<0.01);(4)两组用药过程中均未出现不良反应,血常规、肾功能未见异常改变。结论双环醇片对儿童慢性乙型、丙型肝炎患者有良好的疗效和安全性,且治疗12周的疗效优于治疗4周和8周。
Objective To understand the efficacy and safety of bicycloalcohol tablets in the treatment of childhood hepatitis and provide clinicians with theoretical basis and methods of medication. Methods A randomized, controlled and open clinical study of 148 children with mild to moderate chronic hepatitis B and C were randomly divided into experimental group and control group (75:73), treated with bicyclol and Hugan tablets respectively , Two courses of treatment are 12 weeks. Observed before treatment, after 4 weeks, 8 weeks, 12 weeks of blood, urine, ALT, AST, while observing the general condition and related symptoms and signs. Results (1) The levels of ALT and AST in the treatment group were significantly lower than those in the control group, and the curative effect at 12 weeks was better than that at 4 weeks and 8 weeks (P <0.01). (2) The treatment group had more effective rate than the control group (P <0.01), and the effective rates of 12 weeks in both groups were better than those in 4 weeks and 8 weeks; (3) The treatment group improved the symptoms of liver disease more significantly (P <0.01); (4) No adverse reactions, no abnormal changes in blood, renal function. Conclusion Bicyclic alcohol tablets have good curative effect and safety to children with chronic hepatitis B and C, and the curative effect of 12 weeks is better than that of 4 weeks and 8 weeks.