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目的分析河南省不同病程的HIV感染者同时段检测指标变化特征。方法回顾性研究58例新报告感染者和68例长期感染者,分析2组感染者2011年至2013年期间CD4+T淋巴细胞、病毒载量(Viral Load,VL)变化情况。采用In-house方法,探讨2组感染者原发耐药状况。结果新报告感染者的CD4+T淋巴细胞2年内从658(520,829)个/μl下降至394(274,529)个/μl,长期感染者从481(292,626)个/μl降低至385(247,520)个/μl,前者变化差异有统计学意义(Z=36.64,P<0.05)。组内比较2组感染者VL差异无统计学意义(Z=0.45,P>0.05;Z=0.20,P>0.05),组间比较显示长期感染者VL高于新报告感染者,差异有统计学意义(Z=2.38,P<0.05;Z=3.16,P<0.05)。新报告感染者和长期感染者耐药发生率分别为5.17%(3/58)、11.76%(8/68)。结论新报告感染者病程进展快于长期感染者,应加强全省未治疗感染者的跟踪随访和抗病毒治疗前的耐药检测。
Objective To analyze the characteristics of different indexes of HIV infection in Henan Province during the same period. Methods A retrospective study of 58 newly reported cases and 68 long-term infections was performed. The changes of CD4 + T lymphocytes and Viral Load (VL) in 2 infected patients from 2011 to 2013 were analyzed. The In-house method was used to investigate the primary drug resistance in two groups. Results The newly reported CD4 + T lymphocytes decreased from 658 (520,829) / μl to 394 (274,529) / μl within 2 years, while the proportion of long-term infected patients decreased from 481 (292,626) / μl to 385 (247,520) μl, the former difference was statistically significant (Z = 36.64, P <0.05). There was no significant difference in VL between two groups (Z = 0.45, P> 0.05; Z = 0.20, P> 0.05). The comparison between groups showed that the VL of long-term infection was higher than that of newly reported infection, the difference was statistically significant Significance (Z = 2.38, P <0.05; Z = 3.16, P <0.05). The new report of infection and long-term infection resistance rates were 5.17% (3/58), 11.76% (8/68). Conclusion The progress of new report infection is faster than that of long-term infection. The follow-up of untreated persons in the province and the drug resistance test before antiviral treatment should be strengthened.