度洛西汀治疗多发性硬化伴抑郁状态疗效分析

• 作 者: 唐江威
• 机 构: 黑龙江省齐齐哈尔第一医院神经内二科,
• 出 处: 中国误诊学杂志
• 发表日期: 2010年33期
• 关键词: 多发性硬化 度洛西汀 抑郁状态 治疗应用 汉密顿抑郁量表 生活质量 药物疗法 组内比较 脑电图表现 郁症

目的观察度洛西汀治疗多发性硬化伴抑郁状态的疗效。方法将60例多发性硬化伴抑郁患者按照病情相匹配的原则分为治疗组31例,对照组29例,分别给以度洛西汀,氟西汀治疗;于治疗前、后4周、8周进行汉密顿抑郁量表(HAMD)、汉密顿焦虑量表(HAMA)、日常生活活动能力(ADL)量表测定。结果两组治疗前后HAMD、HAMA和ADL测定组间比较无统计学意义(P>0.05),组内比较有统计学意义(P<0.01)。结论度洛西汀能有效治疗多发性硬化抑郁状态,改善患者生活质量。

Objective To observe the efficacy of duloxetine in the treatment of multiple sclerosis with depression. Methods Sixty patients with multiple sclerosis and depression were divided into treatment group (n = 31) and control group (n = 29) according to the principle of matched condition. The patients were treated with duloxetine and fluoxetine respectively. Week HAMD, HAMA and ADL were measured. Results There was no significant difference between HAMD, HAMA and ADL before and after treatment in both groups (P> 0.05). There was a significant difference between the two groups (P <0.01). Conclusion Duloxetine can effectively treat multiple sclerosis depression and improve the quality of life of patients.