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目的分析重症甲型H1N1流感病例的临床特点,并探讨糖皮质激素在其临床治疗中的作用。方法 49例患者分为对照组及治疗组,对照组采用常规抗病毒及综合支持治疗,治疗组在对照组治疗的基础上加用糖皮质激素治疗。记录两组患者的临床及胸部影像表现,定量分析其在治疗过程中的变化。结果治疗组患者症状较对照组明显改善,治疗组第3、7d症状评分明显低于对照组(P<0.01和<0.05);治疗组肺部炎性渗出较对照组明显减轻(P<0.05);治疗组患者平均住院天数(16.16±1.63d)较对照组(17.67±1.89d)明显缩短(P<0.05)。结论适时、适量使用糖皮质激素能明显改善重症甲型H1N1流感患者的临床表现,缩短病程。
Objective To analyze the clinical features of severe type A (H1N1) influenza and explore the role of glucocorticoid in its clinical treatment. Methods 49 patients were divided into control group and treatment group. The control group was treated with routine anti-virus and comprehensive supportive therapy. The treatment group was treated with glucocorticoid on the basis of the control group. The clinical and thoracic imaging findings of both groups were recorded and their changes during the course of treatment were quantitatively analyzed. Results Compared with the control group, the symptoms in the treatment group were significantly improved, and the symptom scores on the 3rd and 7th days in the treatment group were significantly lower than those in the control group (P <0.01 and <0.05) ). The mean length of hospital stay (16.16 ± 1.63 days) in the treatment group was significantly shorter than that in the control group (17.67 ± 1.89 days) (P <0.05). Conclusions A timely and appropriate amount of glucocorticoids can significantly improve the clinical manifestations of patients with severe type A H1N1 influenza and shorten the course of the disease.