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目的 :探讨西藏拉萨地区乙型肝炎病毒 (HBV)血清免疫学标记的组合模式。方法 共 2 2 4 8例HBV血清样本 ,均以免疫酶联技术 (ELISA)法检测 5项指标。以聚合酶链反应 (PCR)检测HBVDNA。为表述方便 ,设定血清HBV免疫学标记检测项目第 1— 5项的排列顺序为 ( 1 )乙肝表面抗原 (HBsAg) ,( 2 )乙肝表面抗体 (抗 -HBs) ,( 3)乙肝e抗原 (HBsAg) ,( 4 )乙肝e抗体 (抗 -HBe) ,( 5)乙肝核心抗体 (抗 -HBc) ,并以出现阳性项目的序号为该模式代码。结果 本组血清HBV免疫学标记的组合模式共 1 9种 ,并可分为感染期模式组和恢复期模式组。感染期模式组以“1 45”、“1 35”和“1 5”模式为主 ,占全部样本的 4 1 5%。恢复期模式组以“2”和“2 4 5”模式为主 ,占全部样本的 4 0 2 %。结论 本组HBV血清免疫学标记的模式较为复杂。推测HBV血清免疫学标志组合模式转换表现为e系统 ,s系统的转换 ,以及抗 -HBe,抗 -HBe和抗 -HBs的消失等
Objective: To explore the combination pattern of hepatitis B virus (HBV) serum immunological markers in Lhasa, Tibet. Methods A total of 22448 serum samples from HBV patients were tested for 5 indexes by enzyme-linked immunosorbent assay (ELISA). HBVDNA was detected by polymerase chain reaction (PCR). For the convenience of expression, the sequence of items 1 to 5 in the set of serum HBV immunological markers is (1) hepatitis B surface antigen (HBsAg), (2) hepatitis B surface antibody (anti-HBs), (3) hepatitis B e antigen (HBsAg), (4) hepatitis B e antibody (anti-HBe), and (5) hepatitis B core antibody (anti-HBc). Results A total of 19 hepatitis B immunological markers in this group were grouped and divided into infection mode group and convalescent mode group. Infection mode groups were mainly “1 45”, “1 35” and “1 5” modes, accounting for 41.5% of the total samples. The convalescent mode group is dominated by “2” and “2 4 5” modes, accounting for 402% of the total sample. Conclusion This group of HBV serum immunological markers of the pattern is more complicated. It is speculated that the combination of HBV serological immunological markers mode conversion performance for the e system, s system conversion, and anti -HBe, anti -HBe and anti -HBs disappear