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甲胎蛋白(AFP)是目前临床上较为常用及特异的肝癌标志物,但35%~40%的原发性肝癌(PHC)患者,血清中AFP浓度小于400μg/L,而某些良性肝病,如肝硬化、病毒性肝炎等患者,其血清AFP亦可升高,两者的鉴别是目前临床上急待解决的问题之一。近年国内外报道用小扁豆凝集素(LCA)分离AFP异质体,可鉴别不同来源及性质的AFP,对PHC有较高的诊断价值,但LCA用量大,且研究对象多为AFP≥400μg/L的PHC患者,我们着重针对部分AFP<400μg/L的患者,同时对实验方法加以改良,以探讨检测AFP异质体对PHC患者的诊断价值。
Alpha-fetoprotein (AFP) is a commonly used and specific liver cancer marker in clinical practice, but in 35% to 40% of primary liver cancer (PHC) patients, serum AFP concentration is less than 400 μg/L, and some benign liver diseases, For patients with liver cirrhosis and viral hepatitis, serum AFP levels may also increase, and identification of the two is one of the clinically urgent problems to be solved. In recent years, it has been reported at home and abroad that the use of lentil agglutinin (LCA) to separate AFP heteroplasms can identify AFPs of different origins and properties, and has a higher diagnostic value for PHC, but the amount of LCA is large, and the research object is mostly AFP ≥400 μg/ L PHC patients, we focus on the part of AFP <400μg / L patients, while improving the experimental methods to explore the detection of AFP heteroplasmy in the diagnosis of PHC patients.