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氯散疾(Chlorothiazide)应用于临床的时间虽不长,但巳被公认为治疗水肿的最有效的口服利尿剂。最近又发现它的衍生物,即双氢氯散疾(Hydrochlorothi-azide)的效力比氯散疾更大。本文复习了应用这两种药物的经验,并把它们治疗充血性心力衰竭的效用作了比较。应用氯散疾的经验氯散疾的利尿作用,主要是在于它具有抑制肾小管重吸收钠与氯的能力。虽然这个药物具有碳酸酐酶抑制作用,但其作用却与强有力的有机汞化合物相似。福(Ford)氏的实验指出,口服氯散疾2,000毫克,其效果为注射2毫升莫鲁来(Merallurid——一种汞利尿剂)的80%。拜(Bayliss)氏等报告氯散疾与撒利汞(Mersalyl)的作用几乎相等。此外,当汞剂的利尿作
Chlorothiazide has been recognized as the most effective oral diuretic for the treatment of edema, although it has not been used clinically for a long time. It has also recently been found that its derivative, Hydrochlorothi-azide, is more potent than Chlorinamide. This article reviews the experience with both drugs and compares their utility in treating congestive heart failure. The experience of the application of chlorine discomfort chlorine diarrhea diuretic effect, mainly because it has the ability to inhibit tubular reabsorption of sodium and chlorine. Although this drug has carbonic anhydrase inhibition, its effect is similar to powerful organic mercury compounds. An experiment with Ford shows that 2,000 mg of oral chlorine is used to treat 80% of the effects of injecting 2 ml of Meralluride, a mercury diuretic. Bayliss et al. Reported that chlorine dlossia is almost equivalent to Mersalyl. In addition, when the amalgam of urine for