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目的探讨急性有机磷农药中毒(AOPP)轻、中、重度患者脑血流灌注变化的规律。方法回顾分析30例AOPP患者双侧大脑中动脉(MCA)血流频谱形态和血流动力学参数。结果 12例轻度AOPP患者中9例收缩期峰值流速(Vp)、舒张末期流速(Vd)、平均流速(Vm)增高,患者搏动指数(PI)、阻力指数(RI)基本正常;12例中度AOPP患者Vp、Vm、Vd均中度下降,PI、RI均升高;6例重度AOPP患者Vm、Vd明显下降,PI、RI明显升高;大部分患者频谱形态出现异常经颅多普勒超声检查能够对AOPP患者提供丰富的脑血流动力学资料,为患者的病情评估、预后和科研提供可靠的依据,具有重要的临床和科研意义。
Objective To investigate the regularity of changes of cerebral perfusion in patients with mild, moderate and severe acute organophosphorus pesticide poisoning (AOPP). Methods A retrospective analysis of 30 cases of AOPP patients with bilateral middle cerebral artery (MCA) blood flow spectrum morphology and hemodynamic parameters. Results The peak systolic velocity (Vp), end-diastolic velocity (Vd) and mean velocity (Vm) of 9 patients with mild AOPP were significantly increased, and the pulsatility index (PI) and resistance index Degree AOPP patients Vp, Vm, Vd were moderately decreased, PI, RI were increased; 6 patients with severe AOPP Vm, Vd decreased significantly, PI, RI significantly increased; most patients with abnormal morphology of the transcranial Doppler Ultrasonography can provide rich AOPP patients with hemodynamic data to provide a reliable basis for the assessment of disease, prognosis and scientific research, and has important clinical and scientific significance.