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一般认为尿毒症时,免疫反应受损。曾观察到尿毒症患者皮肤对抗原的敏感性减低,移植异体皮肤时,存活时间较长。尿毒症时,免疫抑制的机制不明。作者研究了尿毒症患者体外细胞和体液免疫反应,以阐明免疫抑制的机制。实验发现。使用多细胞系致活物质时,尿毒症患者的细胞对植物血凝素(PHA)与脂多糖(LPS)的反应比正常人减少(P<0.05)。用混合刺激细胞的混合淋巴细胞培养
Uremia is generally believed that the immune response is impaired. Uremia patients have been observed in the skin of the antigen to reduce the sensitivity of allograft skin, the survival time is longer. Uremia, the mechanism of immune suppression is unknown. The authors studied cellular and humoral immune responses in patients with uremia in vitro to elucidate the mechanism of immunosuppression. Experiment find-outs. When using multicellular viable substances, the response of cells from uremic patients to phytohemagglutinin (PHA) to lipopolysaccharide (LPS) was less than normal (P <0.05). Mixed lymphocyte culture with mixed stimulus cells