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目的探讨小儿早期脑性瘫痪(CP)与宫内感染犤弓形虫(toxoplasmosis)、其他、风疹病毒(rubella)、巨细胞病毒(cytomegalicinclu-sion-virus)、单纯疱疹病毒(hexpes),TORCH犦的关系。方法对170例6个月以内早期CP患儿进行TORCH_IgM检测,并将其分为阴性及阳性两组进行高危因素、并发症、头颅CT、脑干听觉诱发电位(BAEP)、头颅B超、脑电图(EEG)等进行了对比研究。结果阳性45例(26.5%),阳性中以巨细胞病毒为最常见,其次为弓形体;单项感染32例,混合感染13例。高危因素中,阳性组以窒息为多见,其次为早产、异常分娩、颅内出血,阴性组窒息与早产发生率相等,并发症:阳性组比阴性组多,特别是智力低下(MR)及听觉障碍为最明显。阳性组的头颅CT、BAEP、头颅B超、EEG异常率比阴性组高,尤以头颅B超为明显,阳性组治疗后在短期内转阴率为91%。结论宫内感染是CP患儿中枢神经损伤、病理损害的重要原因。
Objective To investigate the relationship between early childhood cerebral palsy (CP) and intrauterine infection of toxoplasmosis, other, rubella, cytomegalicinc-sion-virus, herpes simplex virus (hexpes) relationship. Methods TORCH_IgM was detected in 170 children with early CP within 6 months and divided into negative and positive groups for risk factors, complications, head CT, brainstem auditory evoked potential (BAEP), brain B ultrasound, brain EEG, etc. were compared. The results were positive in 45 cases (26.5%), positive for cytomegalovirus was the most common, followed by Toxoplasma; single infection in 32 cases, mixed infection in 13 cases. Risk factors, the positive group asphyxia more common, followed by preterm birth, abnormal delivery, intracranial hemorrhage, the negative incidence of asphyxia and preterm birth were equal, the complication: the positive group than the negative group, especially mental retardation (MR) and hearing Obstacle is the most obvious. Positive CT, BAEP, B-ultrasound and EEG abnormalities were higher in the positive group than those in the negative group, especially in the B-ultrasound group. In the positive group, the negative conversion rate was 91% in the short term. Conclusion Intrauterine infection is an important cause of central nervous system injury and pathological damage in children with CP.