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实验大鼠分为颌下腺切除＋ＣＣｌ_４组，假手术＋ＣＣｌ_４对照组及正常对照组。结果假手术＋ＣＣｌ４第２６时Ⅲ带细胞轻度受损，第４ｄ、８ｄ时受损面积略大，第１２ｄ时大部分细胞恢复；而颌下腺切除＋ＣＣｌ４组则损伤明显，第８ｄ时胞质极度稀疏，１２ｄ时大部分细胞尚未恢复，与假手术组比较，该组Ｆｅｕｌｇｅｎ反应略弱，ＰＡＳ反应减弱，第４～８ｄ时较明显，Ｇ一６一Ｐ，ＳＤＨ活性均减弱。结果表明颌下腺切除导致内源性表皮生长因子缺乏，影响ＣＣｌ_４所致肝损伤的修复。提示颌下腺的某些生物活性物质参与肝细胞损伤后的修复、再生。
Rats were divided into submandibular gland resection + CCl 4 group, sham operation + CCl 4 control group and normal control group. Results At sham operation + CCl4, cells in group Ⅱ were mildly damaged, and the damaged area was slightly larger on the 4th and 8th day. Most of the cells recovered on the 12th day. However, the submandibular gland resection + CCl4 group showed obvious damage and the cytoplasm was extremely sparse on the 8th day , Most of the cells had not recovered on the 12th day. Compared with the sham operation group, Feulgen reaction was slightly weaker, PAS reaction weakened, and obvious on the 4th to 8th day, G-6-P and SDH activities were weakened. The results showed that submandibular gland resection led to the lack of endogenous epidermal growth factor, affecting the repair of liver injury caused by CCl_4. Prompt submandibular gland of certain bioactive substances involved in liver cell injury repair, regeneration.